|Always Drops||Dagannoth bones, Daggannoth hide|
Dagannoth Supreme is most weak to melee attacks. The best weapons to use primarily are the Abyssal whip or tentacle due to its high Strength bonus and fast attack rate, the Saradomin godsword for its special attack, accuracy, and Strength bonus, and the Guthan's warspear, which should only be used in conjunction with the full Barrows set to heal. If a player does not posses a Saradomin godsword, a crystal or dragon halberd is a good alternative special attack weapon.
Note if Dagannoth Prime starts attacking, then you MUST change your protection prayer to Protect from Magic as his hits are devastating and can hit 50. It is highly recommended that meleers stay away from Dagannoth Prime at all costs as he can take you down within a couple hits if not using the right protection prayer. Try to stay near the ladder while killing him in case you need to make a quick escape.
- The biggest threat when killing Dagannoth Supreme is that Dagannoth Prime may respawn while killing Supreme. To save yourself from Prime's hard-hitting magical attacks, turn on Protect from Magic. You can either stick around or leave up the ladder.
- Another possible threat is that Dagannoth Rex may respawn instead of Prime. If this happens, try to position Supreme between you and Rex, and if you are a mage, distract him again like in first wave. However, the mage should feel no inclination to kill Rex; just lure him away. Another strategy is to make use of Entangle or ice spells to deal with Rex.