Once TzTok-Jad is reached, fighting and defeating him requires a lot of skill and decent reflexes with the mouse. It is possible to engage TzTok-Jad using Melee, but it requires skill to switch between the Protect from Melee, Protect from Missiles, and Protect from Magic prayers (recommended for players with much experience). TzTok-Jad uses all three types of combat styles to engage the player. Therefore, a combination of Ranged attacks and Prayer is usually preferred. A sharp eye and swift reflexes are necessary to stand any chance of defeating this monster.
TzTok-Jad has a very long attack range, much like the Tok-Xil encountered earlier on in the Fight Cave. A very useful tip is to try to find out where the orange Ket-Zek spawned in the previous wave. As with all other waves where two enemies of the same type are encountered, the new monster will appear where the off-colored monster spawned. This will allow you to prepare accordingly to prevent Jad from launching a surprise attack.